function L = tdcs_paper_lme(mergeKey, cfg) %TDCS_PAPER_LME Replicate the paper's linear mixed model, verbatim formula: % behavior ~ stim + day + stim:day + (1|rat) % fit with fitlme on the Box-B2 (stim = 1, tDCS) vs Box-A2 (stim = 0, control) % subset of the MERGEKEY grouping ('unmerged'|'mergeA2'|'mergeB2'), over the % full training range. `behavior` = successful reaches, `day` = training day % (raw; day 0 = the paper's "Day 1"), `rat` = subject. Reports the three % effects (stim x day interaction, day, stim) as t(df) / F(1) / p with the % interaction 95% CI, alongside the paper's reference values, and writes % results/paper_.txt. % % (This is the same model as tdcs_lme -- success ~ day*tDCS + (1|subject) -- % written with the paper's exact term order and variable names.) % % L fields: .model .nRats .nObs and .stim/.day/.interaction effect structs % (.estimate .se .t .df .p from Coefficients; .F .df1 .df2 .Fp from ANOVA; % .ci = coefficient 95% CI). Sfull = tdcs_scenario_data([mergeKey '_full']); A = Sfull(ismember(Sfull.group, {cfg.anchorLow, cfg.anchorHigh}), :); tbl = table(); tbl.behavior = A.success; tbl.day = A.day; tbl.stim = double(A.group == cfg.anchorHigh); % Box-B2 = 1, Box-A2 = 0 tbl.rat = A.subject; model = fitlme(tbl, 'behavior ~ stim + day + stim:day + (1|rat)'); C = model.Coefficients; An = anova(model); ci = coefCI(model); L.model = model; L.nRats = numel(unique(tbl.rat)); L.nObs = height(tbl); L.maxDayCtrl = max(tbl.day(tbl.stim == 0)); L.maxDayStim = max(tbl.day(tbl.stim == 1)); L.stim = localTerm(C, An, ci, 'stim'); L.day = localTerm(C, An, ci, 'day'); L.interaction = localTerm(C, An, ci, 'day:stim'); % MATLAB canonicalizes stim:day -> day:stim localReport(L, mergeKey, cfg); end function e = localTerm(C, An, ci, name) i = strcmp(C.Name, name); if ~any(i) error('tdcs_paper_lme:missingTerm', 'No "%s" coefficient (have: %s).', ... name, strjoin(C.Name, ', ')); end ai = strcmp(An.Term, name); e = struct('estimate', C.Estimate(i), 'se', C.SE(i), 't', C.tStat(i), ... 'df', C.DF(i), 'p', C.pValue(i), 'F', An.FStat(ai), 'df1', An.DF1(ai), ... 'df2', An.DF2(ai), 'Fp', An.pValue(ai), 'ci', ci(i, :)); end function localReport(L, mergeKey, cfg) bar = repmat('=', 1, 78); s = sprintf('%s\n', bar); s = [s sprintf('PAPER LME REPLICATION -- %s\n', mergeKey)]; s = [s sprintf('%s\n', bar)]; s = [s sprintf('model: behavior ~ stim + day + stim:day + (1|rat) [stim: %s=1 vs %s=0]\n', ... cfg.anchorHigh, cfg.anchorLow)]; s = [s sprintf('N = %d rats, %d sessions (day raw; day 0 = paper "Day 1")\n', L.nRats, L.nObs)]; s = [s sprintf('day coverage: stim(B2) 0..%d, control(A2) 0..%d\n', L.maxDayStim, L.maxDayCtrl)]; if abs(L.maxDayStim - L.maxDayCtrl) > 2 s = [s sprintf(['** WARNING: unequal day coverage -- the full-range stim:day interaction\n' ... ' extrapolates the control group''s line and is CONFOUNDED here (the paper''s\n' ... ' groups had equal coverage). See the _d0_13 fair-window and phased analyses. **\n'])]; end s = [s sprintf('\n%-26s %-13s %-13s %s\n', 'effect', 't (df)', 'F (df1)', 'p')]; s = [s sprintf('%s\n', repmat('-', 1, 66))]; s = [s localRow('stim x day (interaction)', L.interaction)]; s = [s localRow('day (learning)', L.day)]; s = [s localRow('stim (main, Day 1)', L.stim)]; s = [s sprintf('interaction 95%% CI: [%+.2f, %+.2f]\n', L.interaction.ci(1), L.interaction.ci(2))]; s = [s sprintf(['\nPaper (N=24): interaction t(227)=2.68, F(1)=7.12, p=0.008; ' ... 'day t(227)=9.64,\n F(1)=267.64, p=1.2e-18; stim t(227)=0.23, F(1)=0.053, p=0.81.\n'])]; fprintf('%s', s); thisDir = fileparts(mfilename('fullpath')); resDir = fullfile(thisDir, 'results'); if ~exist(resDir, 'dir'); mkdir(resDir); end fid = fopen(fullfile(resDir, ['paper_' mergeKey '.txt']), 'w'); if fid < 0; error('tdcs_paper_lme:fopen', 'Cannot open results file.'); end cleanup = onCleanup(@() fclose(fid)); %#ok fprintf(fid, '%s', s); end function r = localRow(name, e) r = sprintf('%-26s t(%d)=%6.2f F(%d)=%8.3f p=%.4g\n', name, e.df, e.t, e.df1, e.F, e.p); end