============================================================================== PAPER LME REPLICATION -- mergeNaive (full range) ============================================================================== model: behavior ~ stim + day + stim:day + (1|rat) [stim: Electrode-Box-B2=1 vs Electrode-Box-A2=0] behavior = successful reaches (COUNT per session) N = 11 rats, 170 sessions (day raw; day 0 = paper "Day 1") day coverage: stim(B2) 0..22, control(A2) 0..26 ** WARNING: unequal day coverage -- the full-range stim:day interaction extrapolates the control group's line and is CONFOUNDED here (the paper's groups had equal coverage). See the _d0_13 fair-window and phased analyses. ** ============================================================================== FULL MODEL SUMMARY -- fitlme: behavior ~ stim + day + stim:day + (1|rat) ============================================================================== Linear mixed-effects model fit by ML Model information: Number of observations 170 Fixed effects coefficients 4 Random effects coefficients 11 Covariance parameters 2 Formula: behavior ~ 1 + day*stim + (1 | rat) Model fit statistics: AIC BIC LogLikelihood Deviance 1526.4 1545.2 -757.2 1514.4 Fixed effects coefficients (95% CIs): Name Estimate SE tStat DF pValue {'(Intercept)'} 30.553 4.7932 6.3742 166 1.7469e-09 {'day' } 3.5345 0.33399 10.583 166 2.5084e-20 {'stim' } 10.155 8.0021 1.2691 166 0.2062 {'day:stim' } 1.5835 0.58611 2.7018 166 0.0076138 Lower Upper 21.089 40.016 2.8751 4.1939 -5.6439 25.954 0.42633 2.7407 Random effects covariance parameters (95% CIs): Group: rat (11 Levels) Name1 Name2 Type Estimate {'(Intercept)'} {'(Intercept)'} {'std'} 9.2449 Lower Upper 5.388 15.863 Group: Error Name Estimate Lower Upper {'Res Std'} 19.866 17.802 22.168 effect t(df) / F(df1) p (resid) Satterthwaite: p (df) ---------------------------------------------------------------------------- stim x day (interaction) t(166)= 2.70 F(1)= 7.299 p=0.007614 p=0.007598 (df=170) day (learning) t(166)= 10.58 F(1)=111.990 p=2.508e-20 p=2.011e-20 (df=170) stim (main, Day 1) t(166)= 1.27 F(1)= 1.611 p=0.2062 p=0.217 (df=23) interaction 95% CI: [+0.43, +2.74] HONEST LME -- per-rat random slope (day|rat): interaction F(1,11.4)=0.92, p=0.3565 Satterthwaite DF on the random-INTERCEPT model above stays ~= residual (the slope's error is at session level), so it does NOT fix pseudoreplication. A per-animal random slope collapses the interaction DF toward the animal count -- the honest test. INTERPRETATION - stim x day interaction: SIGNIFICANT (p=0.0076, slope diff=+1.58) -> tDCS (Box-B2) improves FASTER -- benefit accumulates over training. - stim main effect on Day 1 (our day 0): n.s. (p=0.2062) -> groups are comparable on Day 1. Paper (N=24): interaction t(227)=2.68, F(1)=7.12, p=0.008; day t(227)=9.64, F(1)=267.64, p=1.2e-18; stim t(227)=0.23, F(1)=0.053, p=0.81.