============================================================================== PAPER LME REPLICATION -- mergeNaive (days 0-13) ============================================================================== model: behavior ~ stim + day + stim:day + (1|rat) [stim: Electrode-Box-B2=1 vs Electrode-Box-A2=0] behavior = successful reaches (COUNT per session) N = 11 rats, 138 sessions (day raw; day 0 = paper "Day 1") day coverage: stim(B2) 0..13, control(A2) 0..13 (Equal day coverage -- the stim:day interaction over this window is NOT confounded by the full-range coverage imbalance.) ============================================================================== FULL MODEL SUMMARY -- fitlme: behavior ~ stim + day + stim:day + (1|rat) ============================================================================== Linear mixed-effects model fit by ML Model information: Number of observations 138 Fixed effects coefficients 4 Random effects coefficients 11 Covariance parameters 2 Formula: behavior ~ 1 + day*stim + (1 | rat) Model fit statistics: AIC BIC LogLikelihood Deviance 1164.9 1182.4 -576.44 1152.9 Fixed effects coefficients (95% CIs): Name Estimate SE tStat DF pValue {'(Intercept)'} 16.254 4.2865 3.792 134 0.00022519 {'day' } 6.4041 0.42677 15.006 134 1.7662e-30 {'stim' } 8.9845 7.0391 1.2764 134 0.20403 {'day:stim' } 1.7992 0.67672 2.6587 134 0.008801 Lower Upper 7.7764 24.732 5.5601 7.2482 -4.9377 22.907 0.46073 3.1376 Random effects covariance parameters (95% CIs): Group: rat (11 Levels) Name1 Name2 Type Estimate {'(Intercept)'} {'(Intercept)'} {'std'} 8.1481 Lower Upper 4.7633 13.938 Group: Error Name Estimate Lower Upper {'Res Std'} 14.825 13.109 16.766 effect t (df) F (df1) p ------------------------------------------------------------------ stim x day (interaction) t(134)= 2.66 F(1)= 7.068 p=0.008801 day (learning) t(134)= 15.01 F(1)= 225.182 p=1.766e-30 stim (main, Day 1) t(134)= 1.28 F(1)= 1.629 p=0.204 interaction 95% CI: [+0.46, +3.14] INTERPRETATION - stim x day interaction: SIGNIFICANT (p=0.0088, slope diff=+1.80) -> tDCS (Box-B2) improves FASTER -- benefit accumulates over training. - stim main effect on Day 1 (our day 0): n.s. (p=0.2040) -> groups are comparable on Day 1. Paper (N=24): interaction t(227)=2.68, F(1)=7.12, p=0.008; day t(227)=9.64, F(1)=267.64, p=1.2e-18; stim t(227)=0.23, F(1)=0.053, p=0.81.