============================================================================== PAPER LME REPLICATION -- mergeNaive (days 0-10) ============================================================================== model: behavior ~ stim + day + stim:day + (1|rat) [stim: Electrode-Box-B2=1 vs Electrode-Box-A2=0] behavior = successful reaches (COUNT per session) N = 11 rats, 115 sessions (day raw; day 0 = paper "Day 1") day coverage: stim(B2) 0..10, control(A2) 0..10 (Equal day coverage -- the stim:day interaction over this window is NOT confounded by the full-range coverage imbalance.) ============================================================================== FULL MODEL SUMMARY -- fitlme: behavior ~ stim + day + stim:day + (1|rat) ============================================================================== Linear mixed-effects model fit by ML Model information: Number of observations 115 Fixed effects coefficients 4 Random effects coefficients 11 Covariance parameters 2 Formula: behavior ~ 1 + day*stim + (1 | rat) Model fit statistics: AIC BIC LogLikelihood Deviance 952.54 969.01 -470.27 940.54 Fixed effects coefficients (95% CIs): Name Estimate SE tStat DF pValue {'(Intercept)'} 10.33 4.3573 2.3706 111 0.019482 {'day' } 8.0907 0.51948 15.575 111 1.0806e-29 {'stim' } 9.4432 7.1538 1.32 111 0.18954 {'day:stim' } 1.6184 0.8216 1.9699 111 0.051345 Lower Upper 1.6953 18.964 7.0613 9.12 -4.7326 23.619 -0.0096134 3.2465 Random effects covariance parameters (95% CIs): Group: rat (11 Levels) Name1 Name2 Type Estimate {'(Intercept)'} {'(Intercept)'} {'std'} 8.4877 Lower Upper 5.0001 14.408 Group: Error Name Estimate Lower Upper {'Res Std'} 13.352 11.652 15.299 effect t(df) / F(df1) p (resid) Satterthwaite: p (df) ---------------------------------------------------------------------------- stim x day (interaction) t(111)= 1.97 F(1)= 3.880 p=0.05134 p=0.05149 (df=105) day (learning) t(111)= 15.57 F(1)=242.567 p=1.081e-29 p=3.188e-29 (df=107) stim (main, Day 1) t(111)= 1.32 F(1)= 1.742 p=0.1895 p=0.2003 (df=22) interaction 95% CI: [-0.01, +3.25] HONEST LME -- per-rat random slope (day|rat): interaction F(1,10.1)=2.00, p=0.1875 Satterthwaite DF on the random-INTERCEPT model above stays ~= residual (the slope's error is at session level), so it does NOT fix pseudoreplication. A per-animal random slope collapses the interaction DF toward the animal count -- the honest test. INTERPRETATION - stim x day interaction: n.s. (p=0.0513, slope diff=+1.62) -> slopes parallel -- no differential learning rate over this window. - stim main effect on Day 1 (our day 0): n.s. (p=0.1895) -> groups are comparable on Day 1. Paper (N=24): interaction t(227)=2.68, F(1)=7.12, p=0.008; day t(227)=9.64, F(1)=267.64, p=1.2e-18; stim t(227)=0.23, F(1)=0.053, p=0.81.