analysis(matlab): rate + count outputs, variation batch 1
Co-Authored-By: Claude Opus 4.8 <noreply@anthropic.com>
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==============================================================================
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VARIATION: boxa_a2_d0_5 [metric: success RATE (success/attempts)]
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==============================================================================
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model: behavior ~ stim + day + stim:day + (1|rat) (behavior = success RATE (success/attempts))
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day = training day within window (0 = first analyzed day)
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treatment (stim=1): Electrode-Box-B2
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control (stim=0): Electrode-Box-A, Electrode-Box-A2
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N = 7 rats, 42 sessions raw day coverage: treat 0..5, control 0..5
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(equal day coverage over this window)
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==============================================================================
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FULL MODEL SUMMARY -- fitlme
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==============================================================================
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Linear mixed-effects model fit by ML
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Model information:
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Number of observations 42
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Fixed effects coefficients 4
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Random effects coefficients 7
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Covariance parameters 2
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Formula:
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behavior ~ 1 + day*stim + (1 | rat)
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Model fit statistics:
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AIC BIC LogLikelihood Deviance
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-70.223 -59.797 41.112 -82.223
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Fixed effects coefficients (95% CIs):
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Name Estimate SE tStat DF pValue
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{'(Intercept)'} 0.19895 0.036526 5.4467 38 3.2657e-06
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{'day' } 0.049304 0.010134 4.8651 38 2.0216e-05
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{'stim' } -0.034105 0.055794 -0.61127 38 0.54466
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{'day:stim' } 0.043083 0.01548 2.7831 38 0.008341
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Lower Upper
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0.125 0.27289
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0.028788 0.06982
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-0.14705 0.078844
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0.011745 0.074421
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Random effects covariance parameters (95% CIs):
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Group: rat (7 Levels)
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Name1 Name2 Type Estimate
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{'(Intercept)'} {'(Intercept)'} {'std'} 0.039633
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Lower Upper
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0.015473 0.10151
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Group: Error
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Name Estimate Lower Upper
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{'Res Std'} 0.084789 0.067081 0.10717
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effect t(df) / F(df1) p (resid) Satterthwaite: p (df)
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----------------------------------------------------------------------------
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stim x day (interaction) t(38)= 2.78 F(1)= 7.746 p=0.008341 p=0.008621 (df=35)
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day (learning) t(38)= 4.87 F(1)= 23.669 p=2.022e-05 p=2.41e-05 (df=35)
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stim (main, window start) t(38)= -0.61 F(1)= 0.374 p=0.5447 p=0.5472 (df=22)
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interaction 95% CI: [+0.01175, +0.07442]
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HONEST LME (per-animal random slope, day|rat): interaction F(1,9.1)=5.64, p=0.0412
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(Satterthwaite DF ~= residual on this random-intercept model; the random-slope
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model above is the honest learning-rate test -- DF collapses toward the animal count.)
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INTERPRETATION: stim x day interaction SIGNIFICANT positive -- treatment improves FASTER (benefit accumulates) (p=0.008341, slope diff=+0.04308)
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Paper (N=24, count): interaction t(227)=2.68, F(1)=7.12, p=0.008.
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